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Bioreactor Batch Fermentation Bioreactor For Microbiology cell bioreactors

Detail Information

Application


cell bioreactors


Applied for culture of mammal and animal cells through batch feeding or continuous perfusion

The large-scale culture technology of animal cells (hybridoma cells, CHO cells, insect cels, etc.) and its bioreactor engineeringcan be widely used in research, development and industrial production of antibodies, recombinant protein drugs, viral vaccinesand other biotechnological products.

The large-scale culture technology of animal cells and its bioreactor system consisting ofsuch core technolgies as serum-free suspension culture technology, culture process and bioreactor design amplification andenhancement technology, large-scale high-density feeding and continuous perfusion culture technology, computer real-timemonitoring and control technology of culture process, large-scale and high-efficiency production technology of virus products,etc. have been established.



Product Description


External surface polishing, internal no blind angle; tank material is 316L stainless steel material, clip material is stainless steel 304. Internal tank large visual angle liquid level observation sight glasses, 12V automatic delay Philips safety sight lamp; Two 25mm side holes can connect pH, DO and other sensors, with temperature, pH, DO 

Tank: design pressure 0.3 Mpa Clip: design pressure is 0.3 Mpa, use the optimization diversion design, improve the exchange efficiency and tank temperature uniformity.

Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2)

Cooling system with exhaust (organic matter and water of tank will not be lost with the gas exhaust) diaphragm valve control the exhaust not to be infected, specially designed exhaust pipe without the accumulated liquid and bacterium. Using special low shear mixer (turbine) when suspension cell culture.

Siemens S7-200 series PLC + 10-inch tablet computer touch screen display, direct on-site operation (menu type), full English menu and interface; data transmission with the upper computer, sampling and display of tank data, browsing and analysis of system data, Read settings. Control or collect parameters such as pH, DO, tank pressure, temperature, speed, air flow, feed weighing, fermentation broth volume, etc., and can easily calibrate pH and DO electrodes through software; set the initial control state of parameters; have an independent Curve analysis system; directly analyze the historical curve

 

Total volume
5L~1000L
Working volume
30%~70%
Material

316L stainless steel inside and 304 jacket

Diameter: height
 1.5: 2
Stirring system

Top stirring, double mechanical seal. 

 Including 2 gear blades, low shear mixing blades

Sterilization

On-site sterilization auto control or manual control

Clean
 Clean in place by spray ball
Gas control

Provision for mixing at least four gases 

(Air, Oxygen, Nitrogen and CO2)

 Auto control by mass flow meter

Temperature control
Electric heating, water cooling, circulation pump temperature control
Feeding

4 fixed peristaltic pump( standard)

 Variable speed peristaltic pump(optional)
Basic sensor

Stanaded with pH, DO, Temperature, Foam

 Optional: Liquid Level sensor, OD sensor, Turbidity sensor, ORP 

 sensor, Weight system, Live cell sensor etc.

Volume

1~10L (optional)

Load rate

30%~70%

Vessel material

Borosilicate glass

Gassing

Four air intakes

Gas control

Standard: rotor flowmeter (manual )

Optional: mass flowmeter (automatic)

Sterilization

In autoclave

Basic control

Temperature, rotating speed, pH, DO, antifoam, feeds

Peristaltic pump

Standard 4 pcs

Stirring mode

Magnetic stirring

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