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The mystery of two generations of probiotics! Drink yogurt, cure constipation, improve diabetes, and alleviate gastrointestinal diseases!

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The mystery of two generations of probiotics! Drink yogurt, cure constipation, improve diabetes, and alleviate gastrointestinal diseases!

Apr 2,2025

laboratory bioreactor


Among them, probiotics play a huge role in regulating gut microbiota, improving mood, enhancing immunity, and aiding metabolism.

So, who is more suitable for safeguarding your gut health, the first generation of classic probiotics or the second generation of innovative strains?




One generation probiotics are 38 safe strains certified by the National Health Commission, including lactobacilli, bifidobacteria, and others. Their history can be traced back to the early 20th century, for example, the use of Lactobacillus bulgaricus in yogurt has been over 100 years.

They have various functions: Lactobacillus rhamnosus GG strain can improve constipation and diarrhea. Bifidobacterium BB12 is a star strain that enhances immune function. Streptococcus thermophilus helps lactose intolerant individuals better digest dairy products.


bioreactors for cell culture



How to achieve a breakthrough in high-density fermentation of Bifidobacterium bifidum?

These strains not only exist in traditional fermented foods, but are also widely used in modern dietary supplements.

Tips: The fermentation bacteria in ordinary yogurt (such as Lactobacillus bulgaricus) can produce acid and enhance taste, but their colonization ability is weak. If you want to supplement probiotics more efficiently, it is recommended to choose fortified yogurt or dietary supplements labeled as "active probiotics".




stainless steel bioreactor



Second generation probiotics are functional strains screened through modern omics technology, known as "microbial drugs", which can provide treatment options for specific diseases.

Akermann mucophilus: improve diabetes and obesity, enhance the intestinal barrier function by secreting Amuc_1100 protein, and promote the secretion of GLP1.

Pseudomonas aeruginosa: Relieves inflammatory bowel disease, produces anti-inflammatory short chain fatty acids, and inhibits the proliferation of pathogenic bacteria. Clostridium butyricum: regulates intestinal immunity, promotes Treg cell differentiation, and inhibits excessive inflammatory response.

The mechanisms of action of these strains have been visualized through gene sequencing technology, and scientists have also determined the optimal dosage through clinical trials (such as Akk bacteria recommending 10 ^ 9 CFU per day).



conical fermenter stainless



So how to choose probiotics that are suitable for oneself? 


One is to clarify the strain: check the specific strain number on the product packaging (such as LGG, BB12). The second is to ensure activity: choose products labeled with "viable cell count" and use microencapsulation technology to ensure that the strains remain active during storage and transportation. 


Thirdly, clarify the scenario: choose a combination of classic bacterial strains in daily healthcare. For example, for diabetes or intestinal diseases, the second generation innovative strains should be selected after consulting the doctor.



7 gallon fermenter



Precautions: During the use of antibiotics, it is necessary to maintain an interval of at least 2 hours with probiotics. Infants, young children, and pregnant women should choose products with specific strains that have been certified. Pay attention to the temperature when storing (refrigeration at 28 ℃ is optimal).

It can be said that the development of probiotics, from fermentation bacteria in traditional yogurt to engineered strains cultivated in the laboratory, has witnessed a leap in human understanding of health.



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