Must know knowledge on sterilization of fermentation broth and supplementary broth!
Aseptic liquid can prevent contamination by harmful microorganisms, which may consume nutrients, produce toxins, or affect the fermentation process, thereby reducing product yield and quality.
Selection of sterilization method:
Continuous sterilization: Suitable for large-scale production, it can ensure continuous supply of liquid and sterilization efficiency, but requires significant equipment investment.
Sterilization by filtration method: Suitable for heat sensitive materials, it can avoid material denaturation or activity loss that may be caused by heat treatment.
Batch sterilization: suitable for small-scale or intermittent feeding, with simple equipment, but may not be as thorough as continuous sterilization.
Sterilization of ancillary equipment and pipelines: In addition to the liquid, fermentation tanks and their ancillary equipment and pipelines also need to be sterilized to avoid becoming a source of microbial contamination. Common methods include steam sterilization and chemical sterilization.
Fermentation room temperature sterilization technology: provides a new sterilization solution, including:
Fermentation antibacterial solution: By reducing the amount of miscellaneous bacteria, the growth of environmental bacteria can be reduced, which helps to solve the problem of membrane sterilization.
Sterilization in Fermentation Workshop: Intelligent technology is used to achieve room temperature sterilization in large-scale fermentation workshops where humans and machines coexist, avoiding the inconvenience of high temperature and high pressure sterilization.
Ventilation system sterilization: including air compressor pipeline sterilization technology and VHP (vaporized hydrogen peroxide) pipeline sterilization technology, which have the characteristics of almost no corrosion and rapid sterilization.
The selection of sterilization technology should be determined based on specific fermentation processes, material characteristics, and production scale.
Meanwhile, with the development of technology, new sterilization methods may provide more efficient, economical, or suitable solutions for specific applications.
In practical applications, it is also necessary to consider the cost-effectiveness, operational convenience, and environmental impact of sterilization methods.
